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IRTG2403 - Regulatory Genome

 

 

AnnaAnna Monaco

Associated student

Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Mitte (BIMSB)
Hannoversche Str. 28
10115 Berlin, Germany

 

Email: AnnaAlessandra.Monaco[at]mdc-berlin.de

 

 

 

Main Supervisor: Robert Zinzen

Duke partner: Michael Love

 

 

Project: 

During my doctoral research project I aim to investigate how non-coding regulatory regions of the genome define the concerted spatio-temporal patterning of gene expression that leads to different cell types during development. The experimental design consists of a combination of wet lab sample preparation and computational approaches for data analysis. Understanding the regulatory evolution of cell identities and the contribution of transcriptional heterogeneity could pave the way to a better understanding of further biological questions, such as the rise of multicellularity or the genetic basis of human disease.